Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling
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چکیده
منابع مشابه
Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling.
Hedgehog (Hh) signaling plays a major role in multiple aspects of embryonic development, which involves both short- and long-range signaling from localized Hh sources. One unusual aspect of Hh signaling is the autoproteolytic processing of Hh followed by lipid modification. As a consequence, the N-terminal fragment of Hh becomes membrane anchored on the cell surface of Hh-producing cells. A key...
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The proteins of the Hedgehog (Hh) family are secreted proteins exerting short- and long-range control over various cell fates in developmental patterning. The Hh gradient in Drosophila wing imaginal discs consists of apical and basolateral secreted pools, but the mechanisms governing the overall establishment of the gradient remain unclear. We investigated the relative contributions of endocyto...
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Sonic hedgehog (Shh) signaling is required for the growth and patterning of many tissues in vertebrate embryos, but important aspects of the Shh signal transduction pathway are poorly understood. For example, the vesicle transport protein Rab23 is a cell autonomous negative regulator of Shh signaling, but the process affected by Rab23 has not been defined. Here, we demonstrate that Rab23 acts u...
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The Hedgehog (Hh) proteins belong to one of a small number of families of secreted signals that play a central role in the development of most metazoans. hh itself was originally identified as a mutation that causes a “segment polarity” phenotype in Drosophila—as were most of the core components of the Hh signal transduction pathway (Ingham et al. 2011). These components have been highly conser...
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ژورنال
عنوان ژورنال: Development
سال: 2002
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.00178